CyanthOx™ Sea Buckthorn Polyphenols Show Promise in Modulating Aging
CyanthOx™ Sea Buckthorn Polyphenols Show Promise in Modulating Aging and Cellular Senescence:
Aging, an inevitable biological process, is driven by cellular senescence and oxidative stress, which contribute to visible signs of aging and age-related diseases. However, recent research highlights the potential of CyanthOx™, a proprietary Sea Buckthorn polyphenol extract, in mitigating these effects. CyanthOx™ has demonstrated its ability to combat oxidative stress, enhance collagen synthesis, and regulate cellular senescence mechanisms, making it a promising natural solution for anti-aging applications.
Cellular Senescence and the Role of Oxidative Stress
Cellular senescence is a state in which cells stop dividing in response to stress or damage, leading to the accumulation of dysfunctional cells. While transient senescence plays a beneficial role in tissue repair, chronic senescence contributes to aging, tissue dysfunction, and inflammatory conditions.
One primary driver of senescence is oxidative stress, caused by an overproduction of reactive oxygen species (ROS). ROS disrupt cellular function, reduce collagen synthesis, and accelerate collagen degradation, resulting in loss of skin elasticity and visible signs of aging.
Sea Buckthorn proanthocyanidins, trademarked as CyanthOx™, offer a natural and scientifically supported approach to counteract these effects by modulating ROS levels, restoring collagen balance, and mitigating cellular damage.
CyanthOx™, derived from Hippophae rhamnoides (Sea Buckthorn), is produced using an proprietary water extraction and macro porous resin column chromatography (MRCC)process, ensuring a high purity of 91.5%. This extract is rich in bioactive polyphenols, particularly proanthocyanidins, which exhibit potent antioxidant and anti-inflammatory properties.
Recent studies on CyanthOx™ demonstrated its efficacy in combating oxidative stress-induced cellular senescence through several mechanisms:
NeutralizingOxidative Stress:
CyanthOx™enhances the activity of antioxidant enzymes such as superoxide dismutase (SOD)and glutathione (GSH), which neutralize ROS. Additionally, it lowers malondialdehyde (MDA) levels, a marker of lipid peroxidation, offering significant protection against oxidative damage.
Restoring SkinHealth:
CyanthOx™ has shown remarkable results in studies involving human dermal fibroblasts (HSFs)exposed to hydrogen peroxide (H₂O₂)-induced oxidative stress:
Increased CellViability by 64%.
Enhanced Type I Collagen Expression, restoring collagen levels to pre-senescence states, which is critical for maintaining skin elasticity and structural integrity.
RegulatingCollagen Synthesis and Degradation:
CyanthOx™ promotes the synthesis of Type I collagen through the TGF-β1/Smads pathway, a signaling mechanism that drives collagen production. Simultaneously, it inhibits collagen degradation by regulating the MMP/TIMP system, reducing the activity of collagen-degrading enzymes (MMP-1 and MMP-3) while increasingTIMP-1, a natural inhibitor of these enzymes.
ReducingSenescent Cell Accumulation:
CyanthOx™ was found to significantly reduce the number of senescent cells in vitro, restoring their morphology and functionality.
Improving CellMigration and Tissue Repair:
At higher concentrations (100 µg/mL), CyanthOx™ enhanced the migration ability of senescent cells, facilitating tissue repair and wound healing.
CyanthOx™: A Natural Anti-Aging Solution
CyanthOx™ represents a breakthrough in natural anti-aging research, addressing key drivers of cellular aging while promoting skin health and tissue regeneration. By effectively neutralizing oxidative stress, restoring collagen homeostasis and reducing senescent cell accumulation, CyanthOx™ provides a comprehensive approach to aging modulation.
Contact Puredia today to learn more about how CyanthOx™ can transform your products and meet the growing demand for science-backed, natural anti-aging solutions.
Featured Ingredients
Strongest Plant Antioxidants: 9x Stronger than Grape Seed & Acai
100% Plant-based & Vegan
No Additives / Solvent Used
Completely soluble in water
Good Thermal & pH Stability
Patented Technology
This ingredient is certified with:
Reference
Reference
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