New Study Reveals CardiOmegia™ for Cardiovascular Protection Against Oxidative Damage
YANGLING, CHINA – A groundbreaking study conducted by researchers from the College of Food Science and Engineering at Northwest A&F University, highlighted CardiOmegia™ sea-buckthorn procyanidins (SBP), natural polyphenolic compounds, as a promising protective agent against oxidative damage of vascular endothelial cells—a key factor in cardiovascular disease. Recent research published in the journal Frontiers in Nutrition highlights the promising potential of procyanidins derived specifically from sea-buckthorn berries (SBP), effectively regulates cellular oxidative stress and supports vascular health through targeted cellular pathways.
Study Overview
Research provides compelling scientific evidence that CardiOmegia™ sea-buckthorn procyanidins offer significant protective benefits against oxidative damage to vascular endothelial cells. These findings support the potential application of SBP as a natural, safe, and effective agent for cardiovascular health, making it an attractive candidate for future nutritional interventions and functional food formulations aimed at preventing or mitigating cardiovascular diseases.
Key Findings
Sea-buckthorn (Hippophae rhamnoides) is a nutrient-rich shrub traditionally valued for its wide array of bioactive compounds. Among these, procyanidins stand out due to their strong antioxidant and anti-inflammatory properties. The latest study investigated the regulatory effects of SBP on human umbilical vein endothelial cells (HUVECs) subjected to oxidative injury induced by palmitic acid—a common fatty acid known to trigger oxidative stress and endothelial damage.
In this study, researchers demonstrated that SBP treatment effectively protected endothelial cells from damage, maintaining cell viability and structural integrity at safe concentrations (below 400 µg/L). SBP exhibited robust antioxidative activity, significantly reducing reactive oxygen species (ROS) levels, decreasing lactate dehydrogenase (LDH) leakage—a marker of cell membrane damage—and restoring mitochondrial membrane potential (Δψm), thereby improving cellular energy metabolism.
Furthermore, SBP treatment significantly increased nitric oxide (NO) production in endothelial cells, a critical molecule essential for maintaining vascular function and dilation. The researchers used advanced molecular biology techniques, such as quantitative PCR and western blot analyses, to uncover the underlying mechanisms. They identified that SBP's beneficial effects occurred primarily through modulating the p38MAPK/NF-κB signaling pathway, a crucial regulator of inflammatory and oxidative responses. SBP reduced expression of inflammatory markers, including LOX-1 and ICAM-1, and balanced the expression of key enzymes involved in NO synthesis, such as endothelial nitric oxide synthase (eNOS).
About Northwest A&F University
Northwest A&F University is recognized for its commitment to research excellence and innovation, especially in the areas of life sciences and technology. Located in Yangling, Shaanxi, China, the university is dedicated to addressing global challenges in food science, agriculture, and health.
About CardiOmegia™
The highest plant-based Omega7 source in natural triglyceride (tg) form. A premium nutraceutical ingredient standardized to deliver 45% omega-7 in its natural triglyceride form. CardiOmegia™ is sustainably extracted from the fruit of the ancient sea buckthorn plant, grown exclusively on the pristine Tibetan Plateau, using advanced supercritical CO₂ extraction technology. Sourced sustainably from pristine Himalayan Sea Buckthorn berries. Rich in over 190 bioactive nutrients—antioxidants, vitamins, essential fatty acids, and polyphenols—CardiOmegia™️ supports comprehensive mucosal wellness, hydration, and comfort.
About Puredia
Puredia is a global leader in the supply of organic, innovative, and clinically tested nutritional ingredients, specializing in the cultivation and development of Sea Buckthorn products. Established by Dr. Hywel Yuen, Puredia upholds rigorous international certification standards, including USDA, EU, Canada, and China Organic certifications, alongside Halal and Kosher accreditations. The company is distinguished by its robust commitment to scientific research, ensuring the highest levels of efficacy and safety in its offerings. Puredia's dedication to sustainability and social responsibility is evident in its management of organic-certified farms located on the Tibetan Plateau and its contributions to local communities, particularly in enhancing educational opportunities for children in surrounding areas.