New Study Breakthrough CyanthOx™ Natural Potential in Controlling Hypertension

YANGLING, CHINA – Researchers from the College of Food Science and Engineering at Northwest A&F University have published a groundbreaking study in Food Science & Nutrition shown that CyanthOx™ seabuckthorn seed meal peptides represent a promising natural source of ACE inhibitors with the potential to be developed as safe, stable, and effective antihypertensive agents. Utilizing these peptides not only provides a therapeutic alternative for hypertension management but also significantly enhances the value of seabuckthorn seed meal, promoting sustainability and reducing food processing waste.

Study Overview

Research highlights that peptides derived from seabuckthorn seed meal demonstrate significant potential for inhibiting angiotensin-converting enzyme (ACE), a key player in hypertension control. These natural peptides show promising antihypertensive effects, excellent stability, and favorable safety profiles, suggesting a beneficial use of seabuckthorn seed meal as a sustainable therapeutic option.

Key Findings:

In this research, seabuckthorn seed meal proteins were extracted through alkaline extraction and acid precipitation methods, obtaining a protein yield of approximately 27.66%. Following enzymatic digestion using food-grade enzyme preparations, peptides with molecular weights below 3 kDa were isolated, as smaller peptides are generally associated with higher bioactivity.

The extracted peptides exhibited strong ACE inhibitory activity, with an IC50 value of 4.358 mg/mL, indicating their effective antihypertensive potential. Structural analysis using infrared spectroscopy and X-ray diffraction revealed that these peptides primarily contained β-fold and β-turn secondary structures and an amorphous configuration, properties associated with stability and bioactivity.

Further investigation using advanced Quadrupole-TOF LC-MS/MS identified ten peptides with significant ACE inhibitory activity. Molecular docking simulations provided deeper insights into the interaction mechanisms between these peptides and ACE, highlighting specific binding sites and amino acid residues critical for inhibitory function, particularly peptides rich in hydrophobic and acidic amino acids like glutamic acid.

Kinetic studies indicated that seabuckthorn seed meal peptides exhibit non-competitive inhibition, suggesting they bind at sites different from the traditional ACE active centers. Additionally, the peptides maintained their inhibitory activity across a wide range of temperatures and pH values, demonstrating good stability and applicability in diverse processing conditions.

About CyanthOx™

CyanthOx™ is a polyphenol-rich extract from the ancient sea buckthorn plant, including proanthocyanidins and flavonoids. Grown on the Tibetan Plateau, this unique blend is designed to dramatically reverse aging by enhancing cellular regeneration, boosting mitochondrial function, and providing superior antioxidant protection compared to traditional extracts. Ideal for combatting oxidative stress and aging, CyanthOx™ promotes overall cellular health and longevity.

About Puredia
Puredia is a global leader in the supply of organic, innovative, and clinically tested nutritional ingredients, specializing in the cultivation and development of Sea Buckthorn products. Established by Dr. Hywel Yuen, Puredia upholds rigorous international certification standards, including USDA, EU, Canada, and China Organic certifications, alongside Halal and Kosher accreditations. The company is distinguished by its robust commitment to scientific research, ensuring the highest levels of efficacy and safety in its offerings. Puredia's dedication to sustainability and social responsibility is evident in its management of organic-certified farms located on the Tibetan Plateau and its contributions to local communities, particularly in enhancing educational opportunities for children in surrounding areas.